Deep learning-based transformation of H&E stained tissues into special stains

نویسندگان

چکیده

Pathology is practiced by visual inspection of histochemically stained slides. Most commonly, the hematoxylin and eosin (H&E) stain used in diagnostic workflow it gold standard for cancer diagnosis. However, many cases, especially non-neoplastic diseases, additional "special stains" are to provide different levels contrast color tissue components allow pathologists get a clearer picture. In this study, we demonstrate utility supervised learning-based computational transformation from H&E special stains (Masson's Trichrome, periodic acid-Schiff Jones silver stain) using sections kidney needle core biopsies. Based on evaluation three renal pathologists, followed adjudication fourth pathologist, show that generation virtual existing images improves diagnosis several diseases sampled 58 unique subjects. A second study performed found quality generated network was statistically equivalent those through histochemical staining. As into can be achieved within 1 min or less per patient specimen slide, stain-to-stain framework improve preliminary when needed, along with significant savings time cost, reducing burden healthcare system patients.

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ژورنال

عنوان ژورنال: Nature Communications

سال: 2021

ISSN: ['2041-1723']

DOI: https://doi.org/10.1038/s41467-021-25221-2